Titre : |
Etude des mécanismes de résistance aux antibiotiques chez Escherichia coli au niveau des hôpitaux de l’Ouest algérien |
Type de document : |
texte imprimé |
Auteurs : |
AYAD, Amel, Auteur ; DRISSI, m, Auteur |
Editeur : |
Université tlemcen |
Année de publication : |
2017 |
Importance : |
147 p. |
Présentation : |
ill. |
Format : |
30 cm |
Accompagnement : |
cd |
Langues : |
Français (fre) Langues originales : Français (fre) |
Résumé : |
Escherichia coli is an opportunistic pathogen with a high epidemic potential, frequently involved in nosocomial infections. The increase and dissemination of antibiotic resistance in this species is a major public health concern worldwide. The aim of this multicentric study is to make the point on the current situation of antibiotic resistance in E. coli in hospitals of North-Western Algeria.
A total of 240 strains of E. Coli was collected, between October 2008 and June 2012, from various wards of the university hospitals of Tlemcen, Sidi Bel Abbes and Oran. The study of susceptibility to 22 antibiotics, including 13 β-lactams, 4 aminoglycosides, 3 quinolones, trimethoprim/sulfamethoxazole and colistin, revealed high levels of resistance rates for most of the antibiotics tested. Different β-lactam resistance genes were detected with dominance of gene encoding the extended spectrum β-lactamase (ESBL) CTX-M-15 and the emergence of new genes blaTEM-167 and blaCMY-16. Other genes of resistances to aminoglycosides (armA, rmtB, aac(6’)-Ib, aadA and aadB), quinolones (aac(6’)-Ib-cr), trimethoprim/sulfamethoxazole (dfrA) and colistin (mcr-1) were also detected. The dissemination of resistance genes, in the hospitals included in this study, is mainly linked to the circulation of the high-risk international clone ST405 and the transfer of plasmids belonging to different incompatibility groups (IncF, IncFIA, IncL/M, IncI1, IncA/C and IncN) between strains unrelated genetically.
In this study we report for the first time in Algeria, the detection of aminoglycosides resistance genes (armA and rmtB) and colistin resistance gene (mcr-1) in clinical strains of E. coli, pointed out the increase of the frequency of multiresistant strains, in this species, in algerian hospitals, which requires the establishment of control measures to avoid their spread. |
Etude des mécanismes de résistance aux antibiotiques chez Escherichia coli au niveau des hôpitaux de l’Ouest algérien [texte imprimé] / AYAD, Amel, Auteur ; DRISSI, m, Auteur . - Université tlemcen, 2017 . - 147 p. : ill. ; 30 cm + cd. Langues : Français ( fre) Langues originales : Français ( fre)
Résumé : |
Escherichia coli is an opportunistic pathogen with a high epidemic potential, frequently involved in nosocomial infections. The increase and dissemination of antibiotic resistance in this species is a major public health concern worldwide. The aim of this multicentric study is to make the point on the current situation of antibiotic resistance in E. coli in hospitals of North-Western Algeria.
A total of 240 strains of E. Coli was collected, between October 2008 and June 2012, from various wards of the university hospitals of Tlemcen, Sidi Bel Abbes and Oran. The study of susceptibility to 22 antibiotics, including 13 β-lactams, 4 aminoglycosides, 3 quinolones, trimethoprim/sulfamethoxazole and colistin, revealed high levels of resistance rates for most of the antibiotics tested. Different β-lactam resistance genes were detected with dominance of gene encoding the extended spectrum β-lactamase (ESBL) CTX-M-15 and the emergence of new genes blaTEM-167 and blaCMY-16. Other genes of resistances to aminoglycosides (armA, rmtB, aac(6’)-Ib, aadA and aadB), quinolones (aac(6’)-Ib-cr), trimethoprim/sulfamethoxazole (dfrA) and colistin (mcr-1) were also detected. The dissemination of resistance genes, in the hospitals included in this study, is mainly linked to the circulation of the high-risk international clone ST405 and the transfer of plasmids belonging to different incompatibility groups (IncF, IncFIA, IncL/M, IncI1, IncA/C and IncN) between strains unrelated genetically.
In this study we report for the first time in Algeria, the detection of aminoglycosides resistance genes (armA and rmtB) and colistin resistance gene (mcr-1) in clinical strains of E. coli, pointed out the increase of the frequency of multiresistant strains, in this species, in algerian hospitals, which requires the establishment of control measures to avoid their spread. |
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